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Left-back Lee Ridley has been ruled out with a neck injury, with influential winger Peter Beagrie also definately out.
With Ian Kilford and Wayne Graves both struggling to shake off viruses United could find themselves with a heavily depleted midfield.
United have been boosted by the return of Nathan Stanton to training this morning, and as far as possible will field the same side which beat Kidderminster on Tuesday night.
Leyton Orient go into the clash 21st in the league table, and will be without influential left-back Matt Lockwood through suspension.
