Also short-listed for the prize were Scott Brown of Bristol City, Chris Porter of Oldham Athletic and Yeovil Town's Marcus Stewart.
Chris Kamara, chairman of the Powerade Player of the Month Awards panel, said: "Nicky Maynard is the latest in a long line of players to have come through Crewe's famous youth academy.
"He's a striker with great confidence and finishing ability and looks to have a really bright future in the game.
"If he keeps up the form he has shown in September, I'm sure it will not be too long before some of the big clubs start monitoring his progress more closely."