Barcham, a summer signing from Gillingham, has a foot injury and will be assessed prior to the game. The club are confident he will be fit.
He is one of three possible debutants at Adams Park, with Jimmy Ryan and Jordan Robertson in the squad.
Ryan is certain to start, having been one of the few to win praise from boss Alan Knill in an otherwise abysmal day at the office last Saturday in the 5-0 home friendly loss to Barnsley.
Garry Thompson (groin) and Michael O'Connor (knee) both came off the bench against the Tykes and may be in the squad, though it is unlikely they will feature in the starting XI.
Captain Cliff Byrne is the only definite absentee, and he is not likely to feature until September.
Wycombe have a number of injury concerns, with midfielders Stuart Lewis (virus) and Matt Bloomfield (groin) definitely absent.
Centre-halves Dave Winfield and Leon Johnson missed the pre-season defeat to Northampton last weekend through knocks and will be given as long as possible.
Striker Elliot Benyon is missing with a hand injury, while Kevin Betsy is on international duty with the Seychelles.