Barnsley: Bobby Hassell (knee), Marciano Bruma (hand) and Robbie Williams (leg) must sit out.
Coventry: The Sky Blues have doubts over Arjan De Zeeuw, Ellery Cairo, David McNamee, Leon Best, Kevin Thornton and David McNamee.
Betting: H 6-4 A 6-4 D 21-10
Referee: S Mathieson (Cheshire).
Bristol City v QPR (Ashton Gate, 3pm)
Bristol City: Summer signing Ivan Sproule is suspended, while former Iron defender Jamie McCombe is out with a shin problem. Lee Trundle and Michael McIndoe are among their high-profile summer signings set to make debuts.
QPR: Rangers are without six players. Simon Walton broke his leg in pre-season, with Pat Kanyuka (thigh), Gareth Ainsworth (broken shin), and Ray Jones (foot) also injured. Chris Barker and Sampsa Timoska are out through suspension. Lee Camp, John Curtis, Daniel Nardiello and Ben Sahar are all set to make their debuts.
Betting: H evns A 11-5 D 11-5
Referee: K Stroud (Hampshire).
Burnley v West Brom (Turf Moor, 3pm)
Burnley: Robbie Blake, Stephen Jordan and Gabor Kiraly are expected to make their sebuts following summer moves to Lancashire. Albania international Besart Berisha will be on the bench.
West Brom: Robert Koren faces a month out with an eye problem. Pele goes straight into the squad after moving from Southampton this week.
Betting: H 6-4 A 6-4 D 21-10
Referee: E Ilderton (Tyne & Wear).
Cardiff City v Stoke City (Ninian Park, 3pm)
Cardiff: Robbie Fowler is a doubt with a thigh problem. Ross Turnbull, Steve MacLean, Tony Capaldi, Gavin Rae and Trevor Sinclair will make their competitive bows.
Stoke: Rory Delap is in contention to play in a competitive match for the first time since breaking his leg in October. Stephen Wright and Richard Cresswell are in line to make their debuts.
Betting: H 19-20 A 23-10 D 9-4
Referee: S Tanner (Somerset).
Hull City v Plymouth Argyle (KC Stadium 3pm)
Hull: Wayne Brown is a doubt with a hamstring problem
Plymouth: Teenage midfielder Dan Gosling is missing as he is with the England U-17 squad for the World Cup.
Betting: H 21-20 A 21-10 D 11-5
Referee: G Laws (Tyne & Wear).
Ipswich Town v Sheffield Wednesday (Portman Road, 3pm)
Ipswich: Sylvain Legwinski will undergo a late fitness test, but midfielder Gavin Williams is out of action after being told he needs surgery on an ankle ligament injury.
Sheff Wed: Francis Jeffers is in line to make his debut after signing for the Owls on Thursday.
Betting:H 11-10 A 2-1 D 11-5
Referee: R Beeby (Northamptonshire).
Leicester City v Blackpool (Walkers Stadium, 3pm)
Leicester: Hossein Kaebi (thigh) and Carl Cort (hamstring) are out. Patrick Kisnorbo is suspended. But Gareth McAuley and Joe Mattock have shaken off knocks to play.
Blackpool: The Seasiders are still waiting for clearance to play Wes Hoolahan. Paul Rachubka, Michael Flynn, Joh Hills, Stephen Crainey and Gary Taylor-Fletcher are set to make their debuts.
Betting: H 4-6 A 7-2 D 23-10
Referee: A D'Urso (Essex).
Preston North End v Norwich City (Deepdale, 3pm)
Preston: Darren Carter is in the squad after joining from West Brom on Friday. Billy Jones, Kevin Nicholls and Karl Hawley may make their competitive debuts
Norwich: Darren Huckerby is ruled out with a groin injury, as is fellow striker Chris Brown (nose).
Betting: H 19-20 A 23-10 D 9-4
Referee: P Taylor (Hertfordshire).
Sheffield United v Colchester United (Bramall Lane, 3pm)
Sheff Utd: Former Iron striker Billy Sharp will partner James Beattie in attack for the Blades. Gary Naysmith, Lee Hendrie and David Carney are in line to make their first competitive appearances for the club.
Colchester: Summer signing Teddy Sheringham is a doubt with a calf strain, and Kevin Watson is struggling with an Achilles injury.
Betting:H 4-7 A 4-1 D 5-2
Referee: M Jones (Cheshire).
Southampton v Crystal Palace (St Mary's, 3pm)
Southampton: The Saints must make a reshuffle in defence, with Claus Lundekvam injured and Darren Powell suspended. Chris Makin will partner Alan Bennett in the centre of the backline.
Palace: The Eagles are without Paul Ifill and Carl Fletcher due to hamstring injuries, while Mark Kennedy misses out with a groin problem. Summer arrivals Tony Craig and Jeff Hughes are expected to make their Eagles bows.
Betting: H 10-11 A 5-2 D 11-5
Referee: L Probert (Gloucestershire).
Wolverhampton Wanderers v Watford (Molineux, 3pm)
Wolves: Keeper Wayne Hennessey will play in goal with first choice Matt Murray facing six months on the sidelines. Loanee Graham Stack will be on the bench. Winger Matt Jarvis is out with a thigh muscle tear.
Watford: Mart Poom and Matt Jackson will make their debuts, but Jobi McAnuff and Tommy Smith are injury doubts.
Betting: H 11-10 A 21-10 D 21-10
Referee: N Swarbrick (Lancashire).